GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6684514 | 1 | rs6684514 | chr1:156255456 | CCT3 | chr1:156278752-156308195:- | -0.32 | -6.99 | 9.47E-12 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs4118325 | 1 | rs6684571 | chr1:107623224 | NTNG1 | chr1:107682629-108024471:+ | 0.21 | 3.61 | 0.000334 | AIDS |
| THCA | cis | rs12134133 | 1 | rs6684804 | chr1:207439015 | CD55 | chr1:207494817-207534309:+ | 0.19 | 7.52 | 2.67E-13 | Posterior cortical atrophy and Alzheimer's disease |
| THCA | cis | rs6686643 | 1 | rs6686643 | chr1:165616588 | ALDH9A1 | chr1:165631449-165667900:- | 0.13 | 3.71 | 0.000236 | Total ventricular volume |
| THCA | cis | rs6686643 | 1 | rs6686643 | chr1:165616588 | MGST3 | chr1:165600450-165624853:+ | 0.16 | 3.9 | 0.000109 | Total ventricular volume |
| THCA | cis | rs6686842 | 1 | rs6686842 | chr1:41530871 | SCMH1 | chr1:41492875-41707788:- | -0.21 | -4.74 | 2.86E-6 | Height |
| THCA | cis | rs6687813 | 1 | rs6687813 | chr1:169477574 | NME7 | chr1:169101771-169337186:- | -0.4 | -4.25 | 2.54E-5 | D-dimer levels |
| THCA | cis | rs4332428 | 1 | rs66885174 | chr10:4975650 | AKR1C2 | chr10:4964715-5060207:- | 0.38 | 4.95 | 1.02E-6 | Height |
| THCA | cis | rs7523455 | 1 | rs6690097 | chr1:19323050 | TMCO4 | chr1:20008707-20126758:- | -0.15 | -3.35 | 0.000859 | Methotrexate phramacokinetics (acute lymphoblastic leukemia) |
| THCA | cis | rs6690583 | 1 | rs6690464 | chr1:85466369 | MCOLN2 | chr1:85391267-85462796:- | 0.25 | 5.93 | 5.91E-9 | Serum sulfate level |
| THCA | cis | rs6690583 | 1 | rs6690583 | chr1:85466337 | MCOLN2 | chr1:85391267-85462796:- | 0.25 | 5.97 | 4.7E-9 | Serum sulfate level |
| THCA | cis | rs6691722 | 1 | rs6691722 | chr1:24673866 | C1orf201 | chr1:24683490-24741587:- | -0.2 | -4.08 | 5.22E-5 | Response to interferon beta in multiple sclerosis |
| THCA | cis | rs11825709 | 1 | rs66918645 | chr11:93696557 | HEPHL1 | chr11:93754378-93847374:+ | 0.56 | 4.59 | 5.71E-6 | Obesity-related traits |
| THCA | cis | rs6692729 | 1 | rs6692729 | chr1:227018919 | PSEN2 | chr1:227058273-227083804:+ | -0.25 | -5.26 | 2.23E-7 | Electrodermal activity |
| THCA | cis | rs12107539 | 1 | rs66927386 | chr3:151018968 | GPR87 | chr3:151011876-151034636:- | 0.21 | 4.68 | 3.83E-6 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |